接受体外光化学疗法治疗皮肤T细胞淋巴瘤患者的缺铁性贫血
Iron Deficiency Anemia in Patients Undergoing Extracorporeal Photopheresis for Cutaneous T-Cell Lymphoma.
作者信息
Sanford Kimberly W, Anderson Jennifer, Roseff Susan, McPherson Richard A
机构信息
Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.
出版信息
Lab Med. 2019 Jan 1;50(1):29-33. doi: 10.1093/labmed/lmy034.
OBJECTIVE
To describe the indicidence and severity of iron deficiency anemia (IDA) in patients who have received extracorporeal photopheresis (ECP) treatment of cutaneous T-cell lymphoma (CTCL).
METHODS
We performed a retrospective study during a 9-year period of patients with CTCL who were treated with ECP. ECP was performed with UVAR XTS and CELLEX (Therakos Inc). IDA was defined by a drop in hemoglobin (Hb), mean cell volume (MCV), and increased red blood cell distribution width (RDW).
RESULTS
We identified a total of 36 patients; 1 patient was excluded due to severe anemia. In 35 patients, initial hemoglobin values ranged from 9.8 g per dL to 15.9 g per dL, and patients received 4 to 327 ECP treatments. In all, 28 patients showed decreases in Hb of 0.8 g per dL to 6 g per dL during treatments.
CONCLUSION
Chronic ECP led to IDA in 28 of 35 patients with CTCL. IDA occurs due to blood loss when ECP equipment does not return full blood volume to patients.
目的
描述接受体外光化学疗法（ECP）治疗皮肤T细胞淋巴瘤（CTCL）患者中铁缺乏性贫血（IDA）的发生率和严重程度。
方法
我们对接受ECP治疗的CTCL患者进行了为期9年的回顾性研究。ECP使用UVAR XTS和CELLEX（Therakos公司）进行。IDA通过血红蛋白（Hb）下降、平均红细胞体积（MCV）下降和红细胞分布宽度（RDW）增加来定义。
结果
我们共确定了36例患者；1例因严重贫血被排除。在35例患者中，初始血红蛋白值范围为9.8克/分升至15.9克/分升，患者接受了4至327次ECP治疗。总共有28例患者在治疗期间血红蛋白下降了0.8克/分升至6克/分升。
结论
在35例CTCL患者中，28例因慢性ECP导致IDA。当ECP设备未将全血量回输给患者时，IDA是由于失血而发生的。
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