Tran Phuong H L, Duan Wei, Lee Beom-Jin, Tran Thao T D
Deakin University, School of Medicine, Geelong, Australia.
Bioavailability Control Laboratory, College of Pharmacy, Ajou University, Suwon, Korea.
Curr Drug Metab. 2018;19(13):1111-1118. doi: 10.2174/1389200219666180628171100.
Ternary solid dispersions have been demonstrated to be an effective strategy in the improvement of drug absorption and bioavailability.
The applications of the combination of hydrophilic polymers with the potential of hydrophobic polymer incorporation at moderate concentrations have been discussed in recent publications.
In this paper, the general review of this specific type of solid dispersion will be provided with comprehensive understanding of polymer blends of either hydrophilic or hydrophobic polymers. A detailed description of miscible polymers has been developed in recent studies. In addition to dissolution rate improvement, the role of second polymers in crystal growth inhibition and in maintaining the amorphous state will be mentioned.
We also present a summary of characterization techniques commonly used to evaluate solid dispersion and polymer miscibility.
三元固体分散体已被证明是提高药物吸收和生物利用度的有效策略。
近期出版物中讨论了亲水性聚合物与中等浓度下掺入疏水性聚合物潜力的组合应用。
本文将对这种特定类型的固体分散体进行全面综述，以全面了解亲水性或疏水性聚合物的聚合物共混物。近期研究对可混溶聚合物进行了详细描述。除了提高溶解速率外，还将提及第二种聚合物在抑制晶体生长和维持无定形态方面的作用。
我们还总结了常用于评估固体分散体和聚合物混溶性的表征技术。
