从海拉文 C27-C35 副产物合成海胆酮 C1-C15 片段：立体特异性分子内 Kishi 还原。
Synthesis of the Halichondrin C1-C15 Fragment from a Halaven C27-C35 Byproduct: Stereospecific Intramolecular Kishi Reduction.
机构信息
Integrated Chemistry Engine, Eisai AiM Institute , 4 Corporate Drive , Andover , Massachusetts 01810 , United States.
出版信息
Org Lett. 2018 Jul 20;20(14):4295-4297. doi: 10.1021/acs.orglett.8b01715. Epub 2018 Jun 29.
PMID:29956939
Abstract
A byproduct from a Halaven C27-C35 manufacturing process was transformed into a crystalline halichondrin C1-C15 building block by employing a stereospecific intramolecular Kishi reduction as the key step.
摘要
榄香烯 C27-C35 生产工艺的副产品通过采用立体特异性分子内 Kishi 还原作为关键步骤转化为结晶性海兔毒素 C1-C15 砌块。
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