免疫性疾病在携带和不携带 C9orf72 重复扩展的芬兰额颞叶变性队列中的流行情况。
Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers.
机构信息
Institute of Clinical Medicine - Neurology, University of Eastern Finland, FI-70211 Kuopio, Finland.
Institute of Clinical Medicine - Neurology, University of Eastern Finland, FI-70211 Kuopio, Finland; Neurocenter, Neurology, Kuopio University Hospital, FI-70029 Kuopio, Finland.
出版信息
J Neuroimmunol. 2018 Aug 15;321:29-35. doi: 10.1016/j.jneuroim.2018.05.011. Epub 2018 May 22.
Recent studies have suggested a role for immune dysregulation behind the etiology of frontotemporal lobar degeneration (FTLD). Here, we have investigated the prevalence of immunological diseases in FTLD (N = 196) with and without the C9orf72 repeat expansion, Alzheimer's disease (AD) (N = 193) and not cognitively impaired (NCI) subjects (N = 92). The prevalence was 16.3% in FTLD, 13.5% in AD and 15.2% in NCI. Although differences between the groups did not reach statistical significance, the frequency of immunological diseases was the highest in FTLD without the C9orf72 expansion (22/117, 18.8%) and the lowest in FTLD with the expansion (6/56, 10.7%), suggesting that the C9orf72 expansion possibly influences immunological pathways in FTLD.
最近的研究表明，免疫失调在额颞叶变性（FTLD）的病因学中起作用。在这里，我们研究了伴有和不伴有 C9orf72 重复扩展的 FTLD（N=196）、阿尔茨海默病（AD）（N=193）和认知正常（NCI）受试者（N=92）中免疫性疾病的患病率。FTLD 的患病率为 16.3%，AD 为 13.5%，NCI 为 15.2%。尽管组间差异没有达到统计学意义，但 C9orf72 扩展组中免疫性疾病的频率最高（117 例中有 22 例，18.8%），扩展组中频率最低（56 例中有 6 例，10.7%），提示 C9orf72 扩展可能影响 FTLD 中的免疫途径。
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