Molecular Prospecting and Bioinformatics Group - Laboratory of Immunopathology Keizo Asami (LIKA) - Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife, PE, Postal Code 50670-901, Brazil.
Department of Biological Sciences, Xi'an Jiaotong-Liverpool University No 111, Ren Ai Road, Dushu Lake Higher Education Town, Suzhou Industrial Park (SIP), Suzhou, 215123, PR China.
Biomed Pharmacother. 2018 Oct;106:142-148. doi: 10.1016/j.biopha.2018.06.082. Epub 2018 Jun 26.
Breast and cervical cancer are the first and fourth cancer types with the highest prevalence in women, respectively. The developmental profiles of cancer in women can vary by genetic markers and cellular events. In turn, age and lifestyle influence in the cellular response and also on the cancer progression and relapse. The human DEK protein, a histone chaperone, belongs to a specific subclass of chromatin topology modulators, being involved in the regulation of DNA-dependent processes. These epigenetic mechanisms have dynamic and reversible nature, have been proposed as targets for different treatment approaches, especially in tumor therapy. The expression patterns of DEK vary between healthy and cancer cells. High expression of DEK is associated with poor prognosis in many cancer types, suggesting that DEK takes part in oncogenic activities via different molecular pathways, including inhibition of senescence and apoptosis. The focus of this review was to highlight the role of the DEK protein in these two female cancers.
乳腺癌和宫颈癌分别是女性中最常见的第一和第四大癌症类型。女性癌症的发展情况可能因遗传标记和细胞事件而异。反过来，年龄和生活方式也会影响细胞反应，以及癌症的进展和复发。人类 DEK 蛋白是一种组蛋白伴侣，属于特定的染色质拓扑结构调节剂亚类，参与调节 DNA 依赖性过程。这些表观遗传机制具有动态和可逆的性质，已被提议作为不同治疗方法的靶点，特别是在肿瘤治疗中。DEK 的表达模式在健康细胞和癌细胞之间有所不同。DEK 的高表达与许多癌症类型的预后不良有关，这表明 DEK 通过不同的分子途径参与致癌活动，包括抑制衰老和凋亡。本综述的重点是强调 DEK 蛋白在这两种女性癌症中的作用。
