Department of Social Work and Social Administration, University of Hong Kong, Hong Kong, China.
Silver School of Social Work, New York University, New York, United States.
Psychiatry Res. 2018 Sep;267:340-345. doi: 10.1016/j.psychres.2018.06.043. Epub 2018 Jun 20.
This study aims to examine the relationship between the duration of untreated psychosis (DUP) and 14-year outcomes of schizophrenia in a Chinese rural area. Participants with schizophrenia (n = 510) were identified in an epidemiological investigation of 123 572 people aged 15 years and older in 1994 and followed up in 2008 in Xinjin, Chengdu, China. Longer DUP (>6 months) was common in participants (27.3%). In 1994, participants with DUP ≤ 6 months were more likely to have a significantly lower rate of suicide attempts, shorter duration of illness and higher rate of full remission compared with those with DUP > 6 months. No significant differences were found regarding the rates of survival, suicide, death due to other causes and homelessness between individuals with shorter and longer DUP in 2008. Nevertheless, longer DUP (>6 months) of participants in 2008 was significantly associated with higher mean of PANSS total negative and general mental scores, longer duration of illness and higher rate of live alone in the logistic regression model. Earlier identification, treatment and rehabilitation, and family intervention should be addressed when developing mental health policies and delivering community mental health services.
本研究旨在探讨中国农村地区未治疗精神病期（DUP）与精神分裂症 14 年结局之间的关系。在 1994 年对中国成都新津县 123572 名 15 岁及以上人群进行的一项流行病学调查中，共发现了 510 名精神分裂症患者，并于 2008 年对其进行了随访。较长的 DUP（>6 个月）在参与者中很常见（27.3%）。1994 年，DUP≤6 个月的患者自杀未遂率、病程较短且完全缓解率明显低于 DUP>6 个月的患者。然而，2008 年，DUP 较短和较长的患者之间在生存率、自杀、其他原因导致的死亡和无家可归率方面无显著差异。然而，2008 年 DUP（>6 个月）较长的患者在逻辑回归模型中与 PANSS 总分阴性和一般精神评分较高、病程较长和独居率较高显著相关。在制定心理健康政策和提供社区心理健康服务时，应考虑早期识别、治疗和康复以及家庭干预。
