Morphological studies of toxic distal axonopathy.

Distal axonopathy is the most common form of toxic injury to the peripheral nervous system. Morphological studies of the experimental distal axonapathies produced by acrylamide monomer and hexacarbons have lead to a reappraisal of the dying-back hypothesis. These studies have also provided a rationale for many of the clinical findings in humans with distal axonopathies, and have been especially helpful in elucidating the effects of axonal neurotoxins on the central nervous system.