Wahn V
Monatsschr Kinderheilkd. 1985 Jul;133(7):444-58.
Recently interest in pediatric rheumatology has increased. This review tries to summarize our knowledge about pharmacological mechanisms, as well as practical application and adverse of antirheumatic drugs. In addition, forms of treatment which sofar lack any scientific backing are mentioned and discussed. Various data about efficacy and side effects in children are poor or lacking, and current treatment in children is based on analogy conclusions derived from experiences with adult RA. The therapeutic concept presented in this article offers a good chance to improve the functional status of the rheumatic child. However, one should be aware that several controlled trials with antirheumatic drugs in children still have to be performed. Uncertainties have to be replaced by knowledge. This is true also for the surgical treatment mentioned.
最近，对儿童风湿病学的关注有所增加。本综述试图总结我们对抗风湿药物的药理机制、实际应用及不良反应的认识。此外，还提及并讨论了目前缺乏任何科学依据的治疗方式。关于儿童疗效和副作用的各种数据匮乏，目前儿童的治疗是基于从成人类风湿关节炎经验得出的类推结论。本文提出的治疗理念为改善风湿患儿的功能状态提供了良好契机。然而，应该意识到仍需开展多项儿童抗风湿药物的对照试验。不确定性必须被知识所取代。对于提及的手术治疗而言亦是如此。
