Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research , Chandigarh , India.
Department of Cytology & Gynaecological Pathology, Post Graduate Institute of Medical Education and Research , Chandigarh , India .
Ocul Immunol Inflamm. 2019;27(6):1016-1022. doi: 10.1080/09273948.2018.1486437. Epub 2018 Jun 29.
: To describe the clinico-radiological features and long-term outcomes in patients with tubercular dacryoadenitis (TbD) : Retrospective, observational study of TbD patients who underwent a thorough clinical examination, orbital imaging study, and tailored ancillary investigations. Polymerase chain reaction (PCR) and microscopy were done in specific cases. A 4-drug anti-tubercular therapy (ATT) was started and clinical response was monitored in all. Patients with a minimum follow-up of 6 months "off-ATT" were included. : All patients were women and three presented with pain, blepharoptosis, and bilateral involvement. In all, ESR was raised, Mantoux test was positive and orbital imaging revealed enlarged lacrimal gland/s. Positive PCR and granulomatous inflammation on microscopy were seen in two patients. At a mean follow-up of 17.25 months, all women responded with no relapse or clinical recurrence. : Bilateral lacrimal gland enlargement, positive Mantoux & PCR with early response to ATT may provide sufficient evidence for diagnosing TbD.
: 描述结核性泪腺炎（TbD）患者的临床放射学特征和长期预后：对接受全面临床检查、眼眶影像学研究和针对性辅助检查的 TbD 患者进行回顾性观察性研究。在特定情况下进行聚合酶链反应（PCR）和显微镜检查。所有患者均开始接受 4 种药物抗结核治疗（ATT），并监测临床反应。纳入至少随访 6 个月“停药”的患者。 : 所有患者均为女性，3 例表现为疼痛、上睑下垂和双侧受累。所有患者的 ESR 升高，曼托试验阳性，眼眶影像学显示泪腺增大。两名患者的 PCR 阳性和显微镜下的肉芽肿性炎症。在平均随访 17.25 个月后，所有女性均有反应，无复发或临床复发。 : 双侧泪腺增大、曼托试验和 PCR 阳性以及 ATT 的早期反应可能为诊断 TbD 提供充分依据。
