Department of Biomedical Sciences, University of Minnesota Medical School , Duluth, Minnesota.
Physiol Genomics. 2018 Sep 1;50(9):780-806. doi: 10.1152/physiolgenomics.00056.2018. Epub 2018 Jun 29.
Although hearing loss is the most common sensory deficit in Western societies, there are no successful pharmacological treatments for this disorder. Recent experiments have demonstrated that manipulation of intracellular cyclic guanosine monophosphate (cGMP) concentrations can have both beneficial and harmful effects on hearing. In this review, we will examine the role of cGMP as a key second messenger involved in many aspects of cochlear function and discuss the known functions of downstream effectors of cGMP in sound processing. The nitric oxide-stimulated soluble guanylyl cyclase system (sGC) and the two natriuretic peptide-stimulated particulate GCs (pGCs) will be more extensively covered because they have been studied most thoroughly. The cochlear GC systems are attractive targets for medical interventions that improve hearing while simultaneously representing an under investigated source of sensorineural hearing loss.
尽管听力损失是西方社会最常见的感觉缺陷，但目前尚无针对这种疾病的成功药物治疗方法。最近的实验表明，细胞内环鸟苷酸 (cGMP) 浓度的调节可能对听力产生有益和有害的影响。在这篇综述中，我们将探讨 cGMP 作为涉及耳蜗功能许多方面的关键第二信使的作用，并讨论 cGMP 的下游效应器在声音处理中的已知功能。由于它们已被广泛研究，因此将更详细地介绍一氧化氮刺激的可溶性鸟苷酸环化酶系统 (sGC) 和两种利钠肽刺激的颗粒型鸟苷酸环化酶 (pGC)。耳蜗 GC 系统是改善听力的医学干预的有吸引力的靶点，同时也是感觉神经性听力损失的一个研究不足的来源。
