Tiollais P, Pourcel C, Dejean A
Nature. 1985;317(6037):489-95. doi: 10.1038/317489a0.
DNA recombinant technology has radically changed hepatitis B virus (HBV) virology. The genetic organization, transcription and replication of the virus are basically understood, structures of integrated HBV sequences in hepatocellular carcinoma have been characterized, and new vaccines produced by recombinant DNA technique are being developed.
DNA重组技术已从根本上改变了乙型肝炎病毒(HBV)病毒学。该病毒的基因组织、转录和复制已基本明确,肝细胞癌中整合的HBV序列结构已得到鉴定,并且正在研发通过重组DNA技术生产的新型疫苗。