Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, Japan; Department of General Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, Japan.
Department of Regional Medicine and Education, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, Japan.
J Pharmacol Sci. 2018 Jun;137(2):230-232. doi: 10.1016/j.jphs.2018.06.001. Epub 2018 Jun 7.
We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal reflex in rats, suggesting CB could induce visceral antinociception. Pretreatment with either the CB or CB antagonist potently blocked the centrally injected orexin-A-induced antinociceptive action against colonic distension while CB but not CB antagonist blocked the brain ghrelin-induced visceral antinociception. These results suggest that the cannabinoid signaling may be involved in the central orexin- or ghrelin-induced antinociceptive action in a different mechanistic manner.
我们假设大麻素（CB）系统可能介导了脑源性食欲素或胃饥饿素引起的内脏镇痛。腹腔内注射 CB 激动剂 WIN 55212 或 O-花生四烯酸乙醇胺均可增加大鼠结肠扩张引起的腹壁退缩反射的阈值容积，表明 CB 可引起内脏镇痛。用 CB 或 CB 拮抗剂预处理可强烈阻断中枢注射的食欲素-A 对结肠扩张引起的镇痛作用，而只有 CB 拮抗剂而不是 CB 拮抗剂阻断了脑源性胃饥饿素引起的内脏镇痛作用。这些结果表明，大麻素信号可能以不同的机制参与了中枢性食欲素或胃饥饿素诱导的镇痛作用。
