Drulis-Fajdasz D, Rakus D, Wiśniewski J R, McCubrey J A, Gizak A
Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland.
Biochemical Proteomics Group, Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Adv Biol Regul. 2018 Aug;69:35-42. doi: 10.1016/j.jbior.2018.06.001. Epub 2018 Jun 21.
Glycogen synthase kinase-3 (GSK-3) is a constitutively active kinase, involved in regulation of multiple physiological processes. In brain, changes in GSK-3 signaling are related to neurodegenerative issues, including Alzheimer's disease. Due to the wide range of GSK-3 cellular targets, a therapeutic use of the enzyme inhibitors entails significant risk of side effects. Thus, altering the ratio of specific pool of GSK-3 or specific substrates instead of changing the global activity of GSK-3 in brains might be a more appropriate strategy. This paper provides a comprehensive data on abundances of proteins involved in GSK-3 signaling in three regions of young and old mouse brains. It might help to identify novel protein targets with the highest therapeutic potential for treatment of age-related neurodegenerative diseases.
糖原合酶激酶-3（GSK-3）是一种组成型活性激酶，参与多种生理过程的调节。在大脑中，GSK-3信号传导的变化与神经退行性疾病有关，包括阿尔茨海默病。由于GSK-3的细胞靶点范围广泛，使用该酶抑制剂进行治疗会带来显著的副作用风险。因此，改变GSK-3特定库或特定底物的比例，而不是改变大脑中GSK-3的整体活性，可能是一种更合适的策略。本文提供了有关年轻和老年小鼠大脑三个区域中参与GSK-3信号传导的蛋白质丰度的全面数据。这可能有助于识别具有最高治疗潜力的新型蛋白质靶点，用于治疗与年龄相关的神经退行性疾病。
