The Miriam Hospital, Department of Medicine, United States.
Warren Alpert Medical School at Brown University, United States.
Clin Chim Acta. 2018 Oct;485:139-143. doi: 10.1016/j.cca.2018.06.039. Epub 2018 Jun 26.
Snoring, the symptom of partial airway obstruction during sleep, is a common complaint during pregnancy and is associated with adverse perinatal outcomes. Mechanisms underlying this association have not been studied. We investigated the relationship between snoring in pregnancy and maternal serum markers of feto-placental wellbeing.
We conducted a secondary analysis of a cross sectional study designed to investigate perinatal outcomes of sleep-disordered breathing. Women admitted for delivery were systematically selected and answered a questionnaire about snoring using the Multivariable Apnea Prediction Index. Participants who had screening markers measured were included and divided into snorers and non -snorers. Markers measured included first and second trimester Down syndrome screening markers, reported as multiples of the median (MoM). An additional analysis was performed with snorers categorized as acute or chronic snorers based on duration of snoring in relation to pregnancy.
While significant differences were noted in co-morbid maternal medical conditions between snorers and non-snorers, there were no significant differences in the neonatal outcomes assessed between the two groups. No significant differences were noted in any of the first trimester (PAPP-A) or second trimester (AFP, uE3, hCG, inhibin-A) markers between snorers and non-snorers, p > 0.25. In addition, no significant differences in marker levels were noted between acute and chronic snorers.
Snoring is not associated with alterations in the markers of fetal or placental wellbeing tested here and suggests that there are alternative mechanisms underlying the association between snoring and adverse perinatal outcomes.
打鼾是睡眠时部分气道阻塞的症状，是怀孕期间常见的抱怨，并与不良围产结局相关。其相关机制尚未研究。我们研究了怀孕期间打鼾与母体胎儿胎盘健康血清标志物之间的关系。
我们对一项横断面研究进行了二次分析，该研究旨在调查睡眠呼吸障碍的围产结局。系统选择入院分娩的妇女，并使用多变量呼吸暂停预测指数（Multivariable Apnea Prediction Index）回答关于打鼾的问卷。纳入有筛查标志物测量的参与者，并分为打鼾者和非打鼾者。测量的标志物包括唐氏综合征筛查标志物的第一和第二孕期，报告为中位数倍数（MoM）。根据与妊娠相关的打鼾持续时间，对打鼾者进行急性或慢性打鼾者的分类，并进行了额外的分析。
虽然打鼾者和非打鼾者的合并母体医学状况存在显著差异，但两组新生儿结局评估无显著差异。在第一孕期（PAPP-A）或第二孕期（AFP、uE3、hCG、抑制素-A）标志物中，打鼾者和非打鼾者之间均未观察到显著差异（P>0.25）。此外，急性和慢性打鼾者之间的标志物水平也没有显著差异。
打鼾与我们这里测试的胎儿或胎盘健康标志物的改变无关，这表明打鼾与不良围产结局之间存在其他机制。
