人干扰素对源自鼻咽癌的上皮杂交细胞中爱泼斯坦-巴尔病毒诱导的细胞增殖和抗原的影响。

Effects of human interferon on cell proliferation and antigens induced by Epstein-Barr virus in epithelial hybrid cells derived from nasopharyngeal carcinoma.

作者信息

Takimoto T, Ishikawa S, Umeda R, Ogura H, Hatano M

出版信息

Otolaryngol Head Neck Surg. 1985 Aug;93(4):500-4. doi: 10.1177/019459988509300406.

DOI:10.1177/019459988509300406

Abstract

The effects of human leukocyte interferon (HulFN-alpha) and fibroblast interferon (HulFN-beta) on cell growth and induction of antigens related to Epstein-Barr virus (EBV) in a nasopharyngeal carcinoma hybrid cell line (NPC-KT) were studied. HulFN-alpha showed little antiproliferative and anti-EBV effect on NPC-KT cells. On the other hand, HulFN-beta showed modest antiproliferative effect on NPC-KT cells; the effect was dependent on time and HulFN-beta concentration. HulFN-beta alone was ineffective in inhibiting EBV-related antigens, but NPC-KT cells treated for more than 1 week with HulFN-beta inhibited the action of the chemical inducer of EBV, n-butyric acid, and the appearance of EBV-induced early antigen and EB viral capsid antigen was inhibited more than 50% compared with NPC-KT cells treated with n-butyric acid alone.

摘要

研究了人白细胞干扰素（HulFN-α）和成纤维细胞干扰素（HulFN-β）对鼻咽癌杂交细胞系（NPC-KT）中细胞生长及与爱泼斯坦-巴尔病毒（EBV）相关抗原诱导的影响。HulFN-α对NPC-KT细胞几乎没有抗增殖和抗EBV作用。另一方面，HulFN-β对NPC-KT细胞有适度的抗增殖作用；该作用取决于时间和HulFN-β浓度。单独的HulFN-β在抑制EBV相关抗原方面无效，但用HulFN-β处理超过1周的NPC-KT细胞可抑制EBV化学诱导剂正丁酸的作用，与仅用正丁酸处理的NPC-KT细胞相比，EBV诱导的早期抗原和EB病毒衣壳抗原的出现受到的抑制超过50%。