School of Materials Science and Engineering, Nanyang Technological University, Singapore, 637553, Singapore.
Department of Medicine, Stanford University, Stanford, California, 94305, USA.
Chem Asian J. 2018 Nov 16;13(22):3366-3377. doi: 10.1002/asia.201800935. Epub 2018 Aug 20.
In this Focus Review, nanoarchitectonic approaches for mechanical-action-based chemical and biological sensors are briefly discussed. In particular, recent examples of piezoelectric devices, such as quartz crystal microbalances (QCM and QCM-D) and a membrane-type surface stress sensor (MSS), are introduced. Sensors need well-designed nanostructured sensing materials for the sensitive and selective detection of specific targets. Nanoarchitectonic approaches for sensing materials, such as mesoporous materials, 2D materials, fullerene assemblies, supported lipid bilayers, and layer-by-layer assemblies, are highlighted. Based on these sensing approaches, examples of bioanalytical applications are presented for toxic gas detection, cell membrane interactions, label-free biomolecular assays, anticancer drug evaluation, complement activation-related multiprotein membrane attack complexes, and daily biodiagnosis, which are partially supported by data analysis, such as machine learning and principal component analysis.
在本重点综述中，简要讨论了基于机械作用的化学和生物传感器的纳米结构方法。特别是，最近的一些例子，如压电设备，如石英晶体微天平（QCM 和 QCM-D）和膜式表面应力传感器（MSS）被引入。传感器需要精心设计的纳米结构传感材料，以实现对特定目标的敏感和选择性检测。纳米结构方法用于传感材料，如介孔材料、二维材料、富勒烯组装体、支撑脂质双层和层层组装体，被强调。基于这些传感方法，介绍了生物分析应用的示例，用于有毒气体检测、细胞膜相互作用、无标记生物分子分析、抗癌药物评估、补体激活相关多蛋白膜攻击复合物以及日常生物诊断，这些部分得到了数据分析的支持，如机器学习和主成分分析。
