Núñez-Núñez María, Castañeda-Macías Isabel, Sandoval-Fernández Del Castillo Santiago
Unidad de Gestión Clínica, Servicio de Farmacia Hospitalaria, Hospital Virgen Macarena, Sevilla.
Farm Hosp. 2018 Jul 1;42(4):163-167. doi: 10.7399/fh.10921.
The increase of HIV-patients life expectancy leads to a new model of patient with chronic diseases and polymedicated. For this reason we ought to know in clinical practice the prevalence of polypharmacy and drug-drug interactions between the antiretroviral drugs and comedication in our patients in order to identify and prevent them.
A retrospective, descriptive study carried out in > 50 years old patients on antiretroviral treatment. Results: We included 242 patients of whom 148 (61%) were receiving concomitant treatment. 243 potential interactions were detected, where 197 are considered moderate and 46 severe, affecting 110 patients. 35 (76%) interactions were related to boosted protease inhibitors. The main consequence of these interactions was the increase in plasma concentrations of comedication (48%). Statins were the comedication most involved in severe drug-druginteractions (24%), followed by inhaled corticosteroids (15%).
Polypharmacy was found in about half of our study population and the prevalence of drug-drug interactions was high. Hospital pharmacists may play a crucial role in their detection, management and early communication.
艾滋病患者预期寿命的增加导致了一种患有慢性疾病且使用多种药物的新型患者模式。因此，在临床实践中，我们应该了解我们患者中多重用药的患病率以及抗逆转录病毒药物与合并用药之间的药物相互作用，以便识别并预防它们。
对年龄大于50岁的接受抗逆转录病毒治疗的患者进行一项回顾性描述性研究。
我们纳入了242例患者，其中148例（61%）正在接受联合治疗。检测到243种潜在相互作用，其中197种被认为是中度的，46种是严重的，影响了110例患者。35种（76%）相互作用与增效蛋白酶抑制剂有关。这些相互作用的主要后果是合并用药血浆浓度升高（48%）。他汀类药物是最常涉及严重药物相互作用的合并用药（24%），其次是吸入性糖皮质激素（15%）。
在我们大约一半的研究人群中发现了多重用药情况，药物相互作用的患病率很高。医院药剂师在其检测、管理和早期沟通中可能发挥关键作用。
