Aswathy B S, Kumar Velayudhan M, Gulia Kamalesh K
Division of Sleep Research, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695012, Kerala, India.
Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695012, Kerala, India.
Int J Dev Neurosci. 2018 Oct;69:60-67. doi: 10.1016/j.ijdevneu.2018.06.007. Epub 2018 Jun 28.
There is a growing realization that proper sleep during pregnancy is essential for the health of the mother and the offspring. However, there are no reports on the effects of maternal sleep restriction on the sleep-wake profiles of newborns. So, this study was conducted to evaluate the effects of sleep restriction during the third term of pregnancy on the sleep-wake profiles of neonates born to them. The female pregnant Wistar rats were sleep restricted for 5 h/day on gestational days 15-20 by gentle handling. Sleep-wake profiles of the pups born to them and to the control rats were recorded on postnatal days 1-21. Pups of sleep restricted dams had higher active sleep (AS) and lower quiet sleep (QS) as well as wakefulness. Higher ratio of AS to QS, longer duration of sleep cycles, lesser bout frequency and reduced EEG delta power were also observed in these pups, all of which indicated brain immaturity. All these signs of delayed maturation, usually found in premature babies, were observed in the pups of sleep restricted mothers, who had longer gestation period. This report not only shows the importance of sleep during pregnancy, but it also suggests that neonatal sleep monitoring can be used as a tool for early assessment of retarded brain development.
人们越来越意识到孕期的充足睡眠对母亲和后代的健康至关重要。然而，尚无关于母亲睡眠受限对新生儿睡眠-觉醒模式影响的报道。因此，本研究旨在评估孕期第三个阶段睡眠受限对其所生新生儿睡眠-觉醒模式的影响。通过轻柔处理，在妊娠第15至20天对雌性Wistar大鼠进行每天5小时的睡眠限制。记录它们所生幼崽以及对照大鼠所生幼崽在出生后第1至21天的睡眠-觉醒模式。睡眠受限母鼠所生幼崽的主动睡眠（AS）较多，安静睡眠（QS）和觉醒较少。这些幼崽还表现出较高的AS与QS比值、较长的睡眠周期时长、较少的发作频率以及降低的脑电图δ波功率，所有这些都表明大脑不成熟。通常在早产儿中发现的所有这些延迟成熟迹象，在妊娠期较长的睡眠受限母鼠所生幼崽中也观察到了。本报告不仅显示了孕期睡眠的重要性，还表明新生儿睡眠监测可作为早期评估大脑发育迟缓的一种工具。
