Department of Neuroradiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104.
Department of Neuroradiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104.
Acad Radiol. 2019 Apr;26(4):443-449. doi: 10.1016/j.acra.2018.05.021. Epub 2018 Jun 28.
To determine the metabolic effects of developmental venous anomalies (DVAs) and to correlate those effects with conventional magnetic resonance imaging (MRI) findings.
We conducted a retrospective review of MRI and brain 18F-fluorodeoxyglucose positron emission tomography (F-FDG-PET) examinations in subjects with DVAs. Conventional MRI was used to determine DVA number, location, size, and associated parenchymal findings such as atrophy, hemorrhage, cavernoma, capillary telangiectasia, cortical dysplasia/polymicrogyria, and white matter signal abnormality. Qualitative and quantitative measures of relative metabolism in the drainage territory of the DVA were measured on F-FDG-PET.
Fifty-four subjects with 57 DVAs were included in the analysis. 38% were associated with qualitative and quantitative metabolic abnormalities on F-FDG-PET, with decreased metabolism in the parenchyma surrounding all but one of these DVAs. DVAs draining gray matter were significantly more likely to be hypometabolic than those draining only white matter, suggesting that the metabolic effects of DVAs may be underestimated on F-FDG-PET.
Altered metabolism is seen in the drainage territory of a significant proportion of DVAs, suggesting that these anomalies are vascular lesions with abnormal physiologic features.
明确发育性静脉异常（DVAs）的代谢影响，并将这些影响与常规磁共振成像（MRI）结果相关联。
我们对患有 DVA 的患者进行了 MRI 和脑 18F-氟代脱氧葡萄糖正电子发射断层扫描（F-FDG-PET）检查的回顾性研究。常规 MRI 用于确定 DVA 的数量、位置、大小以及相关的实质发现，如萎缩、出血、海绵状血管瘤、毛细血管扩张、皮质发育不良/多微脑回和白质信号异常。F-FDG-PET 测量 DVA 引流区域的相对代谢的定性和定量指标。
分析纳入了 54 名患者的 57 个 DVA。38%的患者在 F-FDG-PET 上存在定性和定量代谢异常，除了一个 DVA 外，所有这些 DVA 周围的实质代谢均降低。引流灰质的 DVA 比仅引流白质的 DVA 更有可能代谢不足，这表明 F-FDG-PET 可能低估了 DVA 的代谢影响。
在相当一部分 DVA 的引流区域中观察到代谢改变，这表明这些异常是具有异常生理特征的血管病变。
