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后真相时代与心脏病学:在ORBITA试验之后,CABANA试验之前。

Post-truth era and cardiology: After ORBITA, before CABANA.

作者信息

Ozeke Ozcan, Cay Serkan, Ozcan Firat, Topaloglu Serkan, Aras Dursun

机构信息

Health Sciences University, Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, Turkey.

Health Sciences University, Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, Turkey.

出版信息

Indian Heart J. 2018 May-Jun;70(3):439-442. doi: 10.1016/j.ihj.2018.04.005. Epub 2018 Apr 22.

Abstract

The evidence-based medicine is rooted in the scientific truth. Oxford Dictionaries has released its 2016 word of the year: "Post-truth," which they define as "relating to or denoting circumstances in which objective facts are less influential in shaping public opinion than appeals to emotion and personal belief". In everything from climate change denial to the anti-vaccine movement, we're seeing the consequences of a failure to engage with scientific evidence. Fake news and post-truth pronouncements are increasingly common in social media and political era and are unfortunately also progressively being applied to the medical science. We also see some evidence of post-truth signals in daily cardiology procedures and guidelines including both interventional cardiology and cardiac electrophysiology. Guideline recommendations made before the randomized-controlled trials (RCT) are published might result in a scenario that the interventions or procedures have been performed on millions of people, costing billions of dollars, leading to unnecessary use of health care resources and often, ending up being even accepted as routine procedures in certain clinical situations. "Justice delayed is justice denied" is a legal cliché meaning that if timely justice is not provided to the sufferer, it loses it importance and violates human rights. In medicine, "The RCT delayed is justice denied", as highlighted by ORBITA (Objective Randomised Blinded Investigation with optimal medical Therapy of Angioplasty in stable angina) trial and as may happen with CABANA (Catheter Ablation versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial) in the post-truth era.

摘要

循证医学植根于科学真理。牛津词典公布了其2016年度词汇:“后真相”,其定义为“与这样的情形相关或表示这样的情形,即在塑造公众舆论方面,客观事实的影响力不如诉诸情感和个人信念”。从否认气候变化到反疫苗运动,我们都看到了未能依据科学证据所带来的后果。假新闻和后真相言论在社交媒体和政治时代越来越普遍,不幸的是,它们也逐渐被应用于医学领域。我们在日常心脏病学程序和指南中也看到了一些后真相信号,包括介入心脏病学和心脏电生理学。在随机对照试验(RCT)发表之前做出的指南推荐可能会导致这样一种情况,即某些干预措施或程序已经在数百万人身上实施,花费了数十亿美元,导致医疗资源的不必要使用,而且在某些临床情况下,这些措施最终甚至被当作常规程序接受。“迟到的正义即被剥夺的正义”是一句法律陈词滥调,意思是如果不及时为受害者提供正义,正义就失去了其重要性并侵犯了人权。在医学领域,正如ORBITA(稳定型心绞痛血管成形术优化药物治疗的客观随机双盲调查)试验所强调的,以及在这个后真相时代CABANA(房颤导管消融与抗心律失常药物治疗试验)可能出现的情况那样,“RCT被推迟即正义被剥夺” 。

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