水杨酸钠对二磷酸腺苷诱导的血小板聚集及血小板摄取45Ca2+的抑制作用。

Inhibitory effect of sodium salicylate on ADP-induced platelet aggregation and on 45Ca2+ uptake into platelets.

作者信息

Irino O, Saitoh K, Ohkubo K, Hashimoto S

出版信息

Thromb Res. 1985 Aug 1;39(3):369-77. doi: 10.1016/0049-3848(85)90232-4.

Abstract

The effects of sodium salicylate (SS) on ADP-induced platelet aggregation and on a metabolism of calcium in platelets were studied, using gel-filtrated platelets (GFP). SS inhibited dose-responsively ADP-induced aggregation in the presence of fibrinogen and Ca2+. It was found that extracellular 45Ca2+ was rapidly taken up into platelets after stimulation by ADP, while SS significantly inhibited this activity. On the other hand, SS had no effect on platelet aggregation induced by 0.11-1.0 microM ionophore A23187. Therefore, it was found that the inhibitory effect of SS on ADP-induced platelet aggregation may be due to the inhibition of the active influx of extracellular Ca2+ into platelets during aggregation.

摘要

使用凝胶过滤血小板（GFP）研究了水杨酸钠（SS）对ADP诱导的血小板聚集以及血小板中钙代谢的影响。在存在纤维蛋白原和Ca2+的情况下，SS剂量依赖性地抑制ADP诱导的聚集。发现ADP刺激后细胞外45Ca2+迅速被血小板摄取，而SS显著抑制该活性。另一方面，SS对0.11 - 1.0微摩尔离子载体A23187诱导的血小板聚集没有影响。因此，发现SS对ADP诱导的血小板聚集的抑制作用可能是由于在聚集过程中抑制了细胞外Ca2+向血小板的主动内流。