Yamazaki N, Shintani M, Saji Y, Nagawa Y
Yakubutsu Seishin Kodo. 1985 May;5(1):1-9.
The effect of neuropeptides and their analogs on anoxia-induced amnesia was examined using one-trial passive avoidance task in mice. Anoxia, produced by the exposure to CO2 immediately after the acquisition of avoidance response, induced amnesia which is shown by a short latency to enter from the safety compartment into the shocked compartment in the retention test conducted 24 hr later. In these anoxia-treated animals, thyrotropin-releasing hormone (TRH: 10-20 mg/kg), its analog DN-1417 (10-20 mg/kg) and ACTH 4-10 (66 micrograms/body), which were given sc 15-60 min before the retention test, markedly prolonged the latency in a dose-dependent manner, indicating a reversal of the amnesia. Arginine- and lysine-vasopressin also reversed the amnesia at a dose of 100 micrograms/body. These results suggest that TRH and DN-1417, known to reverse the amnesia produced by the protein synthesis inhibitor cycloheximide, have ameliorating effects on the retrieval process of memory.
利用小鼠单次被动回避任务，研究了神经肽及其类似物对缺氧诱导失忆的影响。在习得回避反应后立即暴露于二氧化碳产生的缺氧状态会诱发失忆，这在24小时后进行的记忆测试中表现为从安全隔室进入电击隔室的潜伏期缩短。在这些接受缺氧处理的动物中，在记忆测试前15 - 60分钟皮下注射的促甲状腺激素释放激素（TRH：10 - 20毫克/千克）、其类似物DN - 1417（10 - 20毫克/千克）和促肾上腺皮质激素4 - 10（66微克/只），以剂量依赖的方式显著延长了潜伏期，表明失忆得到了逆转。精氨酸血管加压素和赖氨酸血管加压素在剂量为100微克/只时也能逆转失忆。这些结果表明，已知能逆转蛋白质合成抑制剂环己酰亚胺产生的失忆的TRH和DN - 1417，对记忆的提取过程具有改善作用。
