Singh Astha, Malhotra Hardeep Singh, Tripathi Adarsh, Kar Sujita Kumar
Department of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Indian J Psychol Med. 2018 Mar-Apr;40(2):186-188. doi: 10.4103/IJPSYM.IJPSYM_159_17.
Polymicrogyria is a neurodevelopmental abnormality which results in the formation of excessive, small, abnormal, partially fused gyri with superficially located sulci replacing the normal gyral pattern. Intellectual disability, global developmental delay, epilepsy, language deficits, and motor deficits are commonly reported in patients with polymicrogyria. We present here the case of a young male with a rare pattern of bilateral superior frontal and parafalcine frontoparietal polymicrogyria, who had a mild intellectual disability, intractable seizures along with personality changes. This case report also highlights the relevance of neuroimaging in such cases, possible explanations of personality change in polymicrogyria and relevant management issues with a review of the literature.
多小脑回畸形是一种神经发育异常,会导致形成过多、小而异常且部分融合的脑回,表面的脑沟取代了正常的脑回模式。多小脑回畸形患者通常会出现智力残疾、全面发育迟缓、癫痫、语言缺陷和运动缺陷。我们在此报告一例年轻男性病例,其双侧额上回及镰旁额顶叶多小脑回畸形模式罕见,伴有轻度智力残疾、难治性癫痫以及人格改变。本病例报告还强调了神经影像学在此类病例中的相关性、多小脑回畸形中人格改变的可能解释以及相关管理问题,并对文献进行了综述。