Oksanen V, Grönhagen-Riska C, Fyhrquist F, Somer H
Acta Med Scand. 1985;218(1):123-7. doi: 10.1111/j.0954-6820.1985.tb08835.x.
The dissemination and activity of systemic disease was evaluated retrospectively in 50 patients with neurosarcoidosis, 24 of whom presented with neurologic symptoms. During follow-up, five patients never developed detectable systemic disease. In 26 patients, sarcoidosis had previously been diagnosed, but in 11 (42%) of them the neurologic symptoms were initially not connected with this disease. During follow-up, extraneural features were those of sarcoidosis in general. However, 23 patients (46%) had normal chest X-ray on admission to neurologic examinations. Fourteen (35%) of 40 examined patients had ocular changes, 13 (33%) of 39 hypercalciuria and 13 (26%) of 50 skin manifestations. Serum angiotensin converting enzyme (ACE) was elevated in only 31% of the patients. Measureable amounts of ACE were recorded in the cerebrospinal fluid from 13 of 17 examined patients. During follow-up the activity of neurosarcoidosis seemed to be linked to the course of systemic disease in general.
对50例神经结节病患者的全身疾病传播及活动情况进行了回顾性评估，其中24例出现神经症状。随访期间，5例患者从未出现可检测到的全身疾病。26例患者之前已被诊断为结节病，但其中11例（42%）的神经症状最初与该疾病无关。随访期间，神经外表现总体上为结节病的表现。然而，23例患者（46%）在接受神经科检查入院时胸部X线检查正常。40例接受检查的患者中有14例（35%）出现眼部改变，39例中有13例（33%）出现高钙尿症，50例中有13例（26%）出现皮肤表现。仅31%的患者血清血管紧张素转换酶（ACE）升高。17例接受检查的患者中有13例脑脊液中记录到可测量的ACE量。随访期间，神经结节病的活动似乎总体上与全身疾病的病程相关。
