Protein Kinase C: The Drug Target One Must See.
作者信息
Das Joydip
机构信息
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA.
出版信息
Med Chem (Los Angeles). 2012;2(5). doi: 10.4172/2161-0444.1000e103. Epub 2012 Jul 25.
Abstract
摘要
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本文引用的文献
1
Crystal structure and allosteric activation of protein kinase C βII.蛋白激酶 CβII 的晶体结构与别构激活。
Cell. 2011 Jan 7;144(1):55-66. doi: 10.1016/j.cell.2010.12.013.
2
Wealth of opportunity - the C1 domain as a target for drug development.机遇无限——C1结构域作为药物开发靶点
Curr Drug Targets. 2008 Aug;9(8):641-52. doi: 10.2174/138945008785132376.
3
The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury.蛋白激酶Cδ和ε同工酶在心肌缺血/再灌注损伤调节中的作用。
Biochem Soc Trans. 2007 Nov;35(Pt 5):1040-2. doi: 10.1042/BST0351040.
4
Targeting the protein kinase C family: are we there yet?靶向蛋白激酶C家族：我们做到了吗？
Nat Rev Cancer. 2007 Jul;7(7):554-62. doi: 10.1038/nrc2168.
5
Happy birthday protein kinase C: past, present and future of a superfamily.蛋白激酶C生日快乐：一个超家族的过去、现在与未来
Pharmacol Res. 2007 Jun;55(6):461-6. doi: 10.1016/j.phrs.2007.05.005. Epub 2007 May 18.
6
Protein kinase C and alcohol addiction.蛋白激酶C与酒精成瘾
Pharmacol Res. 2007 Jun;55(6):570-7. doi: 10.1016/j.phrs.2007.04.008. Epub 2007 Apr 29.
7
Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).蛋白激酶C-θ（PKCθ）的催化结构域晶体结构
J Biol Chem. 2004 Nov 26;279(48):50401-9. doi: 10.1074/jbc.M409216200. Epub 2004 Sep 13.
8
Protein kinase C isozymes as potential targets for anticancer therapy.蛋白激酶C同工酶作为抗癌治疗的潜在靶点。
Curr Cancer Drug Targets. 2004 Mar;4(2):125-46. doi: 10.2174/1568009043481579.
9
The protein kinase complement of the human genome.人类基因组的蛋白激酶补体。
Science. 2002 Dec 6;298(5600):1912-34. doi: 10.1126/science.1075762.
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Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions.蛋白激酶C：通过磷酸化、辅因子和大分子相互作用进行的结构和空间调节
Chem Rev. 2001 Aug;101(8):2353-64. doi: 10.1021/cr0002801.
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