Quebec Heart and Lung Institute, Québec, Canada; Faculty of Medicine, Université Laval, Québec, Canada.
Quebec Heart and Lung Institute, Québec, Canada; Faculty of Pharmacy, Université Laval, Québec, Canada.
Prog Cardiovasc Dis. 2018 Jul-Aug;61(2):103-113. doi: 10.1016/j.pcad.2018.06.004. Epub 2018 Jun 28.
Obesity is recognized as a heterogeneous condition in which individuals with similar body mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to obesity-related cardiometabolic complications is not solely mediated by overall body fat mass, but is largely dependent upon individual differences in regional body fat distribution and ability of subcutaneous adipose tissue to expand. The present review will discuss to what extent the individual variation in body fat distribution is one of the clinical key variables explaining the metabolic heterogeneity of obesity and its related cardiovascular risk. We will present the evidence for the complex nature of the relationship between obesity and cardiovascular disease, outline our current understanding of the mechanisms involved, and identify future direction of research pertinent to this interaction.
肥胖被认为是一种异质性疾病，即使身体质量指数相似的个体也可能具有不同的代谢和心血管风险特征。肥胖相关的心血管代谢并发症的易感性不仅仅是由总体体脂肪量决定的，还在很大程度上取决于个体之间的区域体脂肪分布差异和皮下脂肪组织的扩张能力。本综述将讨论个体间体脂肪分布的差异在多大程度上是解释肥胖及其相关心血管风险的代谢异质性的临床关键变量之一。我们将介绍肥胖与心血管疾病之间关系的复杂性证据，概述我们目前对相关机制的理解，并确定与这种相互作用相关的未来研究方向。
