Anis Saar, Mosek Amnon
Neurology Department, Sourasky Medical Center, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University.
Harefuah. 2018 Jun;157(6):370-373.
Evidence of epigenetics' role in pain response is accumulating in recent years. Tightly regulated epigenetic alterations on DNA and histones in the sensory circuit shape the physiological response to injury. Altering those epigenetic processes hinders therapeutic potential in pain. This review provides an overview of epigenomic modification in the development of chronic pain, and summarizes the therapeutic potential to alter epigenetic processes.
近年来，表观遗传学在疼痛反应中作用的证据不断积累。感觉回路中DNA和组蛋白上受到严格调控的表观遗传改变塑造了对损伤的生理反应。改变这些表观遗传过程会阻碍疼痛治疗的潜力。本综述概述了慢性疼痛发展过程中的表观基因组修饰，并总结了改变表观遗传过程的治疗潜力。
