Das S, Bhargava H N
Arch Int Pharmacodyn Ther. 1985 Jul;276(1):82-91.
Short-term administration of LiCl (4 mEq/kg) reduced blood pressure of SH rats but had no effect on WKY animals. Lower doses of lithium, however, did not alter blood pressure in the SH or WKY rats. Acute and chronic administration of lithium had no appreciable effect on heart rate. Although all rats gained weight during the treatment period, the per cent increase in body weight of LiCl (4 mEq/kg) treated SH and WKY rats was significantly lower than the corresponding vehicle treated animals. Angiotensin converting enzyme (ACE) activity of anterior pituitary of WKY rats was significantly higher than that of SH rats. ACE activity of neurohypophysis, instead was lower in WKY rats than in SH rats. ACE activities in plasma, striatum and hypothalamus of SH and WKY rats did not differ. After short-term lithium treatment (4 mEq/kg), plasma ACE activity was significantly reduced only in the SH animals although ACE activities in pituitary, striatum or hypothalamus remained unaffected in the SH animals. The results suggest that the antihypertensive effect of lithium in SH animals may be related to decreased plasma ACE activity.
短期给予氯化锂（4 毫当量/千克）可降低自发性高血压（SH）大鼠的血压，但对正常血压的京都威斯塔（WKY）大鼠无影响。然而，较低剂量的锂对 SH 或 WKY 大鼠的血压没有改变。锂的急性和慢性给药对心率没有明显影响。尽管所有大鼠在治疗期间体重均增加，但接受氯化锂（4 毫当量/千克）治疗的 SH 和 WKY 大鼠的体重增加百分比显著低于相应的溶剂对照组动物。WKY 大鼠垂体前叶的血管紧张素转换酶（ACE）活性显著高于 SH 大鼠。相反，WKY 大鼠神经垂体的 ACE 活性低于 SH 大鼠。SH 和 WKY 大鼠血浆、纹状体和下丘脑中的 ACE 活性没有差异。短期锂治疗（4 毫当量/千克）后，仅 SH 动物的血浆 ACE 活性显著降低，尽管 SH 动物垂体、纹状体或下丘脑中的 ACE 活性未受影响。结果表明，锂对 SH 动物的降压作用可能与血浆 ACE 活性降低有关。
