Department of Pharmacy, BRAC University, 1212 Dhaka, Bangladesh.
Biomolecules. 2018 Jun 29;8(3):44. doi: 10.3390/biom8030044.
Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide⁺ (NAD⁺) dependent enzyme and stress response protein that has sparked the curiosity of many researchers in different branches of the biomedical sciences. A unique member of the known Sirtuin family, SIRT6 has several different functions in multiple different molecular pathways related to DNA repair, glycolysis, gluconeogenesis, tumorigenesis, neurodegeneration, cardiac hypertrophic responses, and more. Only in recent times, however, did the potential usefulness of SIRT6 come to light as we learned more about its biochemical activity, regulation, biological roles, and structure Frye (2000). Even until very recently, SIRT6 was known more for chromatin signaling but, being a nascent topic of study, more information has been ascertained and its potential involvement in major human diseases including diabetes, cancer, neurodegenerative diseases, and heart disease. It is pivotal to explore the mechanistic workings of SIRT6 since future research may hold the key to engendering strategies involving SIRT6 that may have significant implications for human health and expand upon possible treatment options. In this review, we are primarily concerned with exploring the latest advances in understanding SIRT6 and how it can alter the course of several life-threatening diseases such as processes related to aging, cancer, neurodegenerative diseases, heart disease, and diabetes (SIRT6 has also shown to be involved in liver disease, inflammation, and bone-related issues) and any recent promising pharmacological investigations or potential therapeutics that are of interest.
Sirtuin 6 (SIRT6) 是一种烟酰胺腺嘌呤二核苷酸⁺ (NAD⁺) 依赖的酶和应激反应蛋白，引起了不同医学领域研究人员的极大兴趣。SIRT6 是已知 Sirtuin 家族中的一个独特成员，在与 DNA 修复、糖酵解、糖异生、肿瘤发生、神经退行性变、心脏肥厚反应等相关的多种不同分子途径中具有多种不同的功能。然而，直到最近，我们才更多地了解了 SIRT6 的生化活性、调节、生物学作用和结构，从而发现了 SIRT6 的潜在有用性。直到最近，SIRT6 还主要与染色质信号有关，但作为一个新兴的研究课题，更多的信息已经被确定，并且它可能参与包括糖尿病、癌症、神经退行性疾病和心脏病在内的重大人类疾病。探索 SIRT6 的作用机制至关重要，因为未来的研究可能为涉及 SIRT6 的策略提供关键，这可能对人类健康具有重要意义，并扩大潜在的治疗选择。在这篇综述中，我们主要关注的是探索理解 SIRT6 的最新进展，以及它如何改变几种危及生命的疾病的进程，如与衰老、癌症、神经退行性疾病、心脏病和糖尿病相关的过程（SIRT6 也与肝脏疾病、炎症和骨骼相关问题有关），以及任何最近有前途的药理学研究或潜在的治疗方法。
