右心-肺循环单元与左心瓣膜病。

The Right Heart-Pulmonary Circulation Unit and Left Heart Valve Disease.

机构信息

Department of Cardiology, University Hospital of Nancy, Lorrain Institute for Heart and Vessels, F-54500 Vandoeuvre-lès-Nancy, France.

Department of Cardiology, University Hospital of Nancy, Lorrain Institute for Heart and Vessels, F-54500 Vandoeuvre-lès-Nancy, France; IADI Laboratory (DIAGNOSIS AND INTERVENTIONAL ADAPTIVE IMAGING), INSERM U947, University of Lorraine, F-54500 Nancy, France.

出版信息

Heart Fail Clin. 2018 Jul;14(3):431-442. doi: 10.1016/j.hfc.2018.03.009.

DOI:10.1016/j.hfc.2018.03.009

PMID:29966640

Abstract

Valvular heart disease (VHD) is frequently accompanied by pulmonary hypertension (PH). In asymptomatic patients, PH is rare, although the exact prevalence is unknown and mainly stems from the severity of the VHD and the presence of diastolic dysfunction. PH can also be depicted during exercise echocardiography. PH either at rest or during exercise is also a powerful determinant of outcome and is independently associated with reduced survival, regardless of the severity of the underlying valvular pathology. Therefore, because PH is a marker of poor prognosis, assessment of PH in VHD is crucial for risk stratification and management of patients with VHD.

摘要

心脏瓣膜病（VHD）常伴有肺动脉高压（PH）。在无症状患者中，PH 较为罕见，尽管确切的患病率尚不清楚，主要与 VHD 的严重程度和舒张功能障碍的存在有关。PH 也可在运动超声心动图中描述。静息或运动时的 PH 也是结局的有力决定因素，与生存时间缩短独立相关，而与潜在瓣膜病变的严重程度无关。因此，由于 PH 是预后不良的标志物，因此在 VHD 中评估 PH 对于 VHD 患者的风险分层和管理至关重要。