Instituto de Química, Universidade Estadual Paulista "Julio de Mesquita Filho", UNESP, R. Prof. Francisco Degni 55, P.O. Box 355, 14800-900 Araraquara, SP, Brazil.
Instituto de Química, Universidade Estadual Paulista "Julio de Mesquita Filho", UNESP, R. Prof. Francisco Degni 55, P.O. Box 355, 14800-900 Araraquara, SP, Brazil.
Spectrochim Acta A Mol Biomol Spectrosc. 2018 Nov 5;204:432-435. doi: 10.1016/j.saa.2018.06.049. Epub 2018 Jun 15.
A simple, fast, low-cost, portable, and eco-friendly method using a spot test on a paper platform, together with diffuse reflectance spectroscopy, was developed and validated for the quantification of aluminum hydrochloride, a potential neurotoxic agent, in antiperspirant samples. The determination of aluminum hydrochloride was performed at a wavelength of 615 nm, by measuring consumption of the purple colorimetric reagent Alizarin S, due to reaction with aluminum. The linear range was from 10.0 to 125.0 mg L and could be described by the equation: A = 0.4479 - 0.002543 C (R = 0.999). The limits of detection (LOD) and quantification (LOQ) were 3.06 and 10.2 mg L, respectively. The method was specific, accurate, and repeatable, with relative standard deviation (RSD) <5.0%. The recovery was between 92.2 and 103.4%. The method was successfully used for the determination of aluminum hydrochloride in commercial antiperspirant samples, revealing concentrations below the maximum permitted by current legislation.
开发并验证了一种简单、快速、低成本、便携且环保的方法，使用纸质平台上的斑点测试和漫反射光谱法，用于定量分析止汗剂样品中的潜在神经毒性物质盐酸铝。通过测量紫色比色试剂茜素 S 因与铝反应而消耗的量，在 615nm 波长处进行盐酸铝的测定。线性范围为 10.0 至 125.0mg/L，可以用方程表示为：A=0.4479-0.002543C（R=0.999）。检测限（LOD）和定量限（LOQ）分别为 3.06 和 10.2mg/L。该方法具有特异性、准确性和可重复性，相对标准偏差（RSD）<5.0%。回收率在 92.2%至 103.4%之间。该方法成功用于测定商业止汗剂样品中的盐酸铝，结果表明浓度低于现行法规允许的最大值。
