4-氨基吡啶可诱导脊髓背角细胞的皮肤感受野扩大。
4-Aminopyridine induces expansion of cutaneous receptive fields of dorsal horn cells.
作者信息
Semba K, Geller H M, Egger M D
出版信息
Brain Res. 1985 Sep 23;343(2):398-402. doi: 10.1016/0006-8993(85)90765-6.
PMID:2996702
Abstract
Systemic administration of 4-aminopyridine (4-AP) increased the size of the cutaneous receptive fields of 9 of the 15 dorsal horn cells tested. These receptive fields were on the feet and toes of the hind limbs of cats. Receptive field sizes increased with increasing doses of 4-AP. However, 4-AP administration did not change the responses of dorsal horn cells to graded mechanical stimuli administered near the centers of their receptive fields.
摘要
对15个受试背角细胞中的9个进行全身性给予4-氨基吡啶（4-AP）后，其皮肤感受野的大小增加。这些感受野位于猫后肢的足部和脚趾。感受野大小随4-AP剂量增加而增大。然而，给予4-AP并未改变背角细胞对在其感受野中心附近施加的分级机械刺激的反应。
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