Gagnon R M, Presant S, Morissette M
Can J Cardiol. 1985 Jul-Aug;1(4):259-62.
Intravenous labetalol was evaluated in 10 patients with stable angina without heart failure. Mean dose was 1.75 mg/kg (range 1.5-2 mg/kg). Measurements were taken within one minute after the injection, and at 1, 5 and 15 minutes thereafter. Labetalol significantly decreased blood pressure and increased heart rate. Peak aortic flow velocity increased only significantly at 1 minute; dP/dt+ max. was significantly decreased during all the measurements. Left ventricular end diastolic pressure did not change. Thus in patients without failure left ventricular function remained stable despite the negative inotropic effects of labetalol.
对10例无心力衰竭的稳定型心绞痛患者使用静脉注射拉贝洛尔进行评估。平均剂量为1.75mg/kg（范围为1.5 - 2mg/kg）。在注射后1分钟内以及之后的1、5和15分钟进行测量。拉贝洛尔显著降低血压并增加心率。主动脉血流峰值速度仅在1分钟时显著增加；在所有测量期间，dP/dt+ max显著降低。左心室舒张末期压力未改变。因此，在无心力衰竭的患者中，尽管拉贝洛尔具有负性肌力作用，但左心室功能仍保持稳定。
