Soleimani Asl Sara, Roointan Amir, Bergen Hugo, Amiri Shayan, Mardani Parastoo, Ashtari Niloufar, Shabani Ronak, Mehdizadeh Mehdi
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Basic Clin Neurosci. 2018 Mar-Apr;9(2):101-106. doi: 10.29252/nirp.bcn.9.2.101.
Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. In humans, A118G Single Nucleotide Polymorphisms (SNP) on μ-Opioid Receptor (MOR), 36 G>T in κ-Opioid Receptor (KOR), and T921C in the δ-Opioid Receptor (DOR) have been found to associate with substance dependence.
To investigate the association between opioid receptors gene polymorphism and heroin addiction, 100 control subjects with no history of opioid use, and 100 heroin addicts (50% males and 50% females) in Tehran (capital of Iran), were evaluated. A118G, 36 G>T, and T921C SNPs on the MOR, KOR, DOR genes, respectively, were genotyped by sequencing.
We found no differences in either allele or genotype frequency for MOR, KOR and DOR genes SNPs between controls and subjects addicted to heroin.
The relationships among polymorphisms may be important in determining the risk profile for complex diseases such as addiction, but opioid addiction is a multifactorial syndrome which is partially hereditary and partially affected by the environment.
基因通常具有多种多态性，这些多态性在不同个体中会相互作用并与环境相互影响。阿片受体的变异性会影响阿片类药物戒断和成瘾。在人类中，已发现μ-阿片受体（MOR）上的A118G单核苷酸多态性（SNP）、κ-阿片受体（KOR）上的36G>T以及δ-阿片受体（DOR）上的T921C与物质成瘾有关。
为了研究阿片受体基因多态性与海洛因成瘾之间的关联，对伊朗首都德黑兰的100名无阿片类药物使用史的对照受试者和100名海洛因成瘾者（50%为男性，50%为女性）进行了评估。分别通过测序对MOR、KOR、DOR基因上的A118G、36G>T和T921C SNPs进行基因分型。
我们发现对照受试者和海洛因成瘾受试者之间，MOR、KOR和DOR基因SNP的等位基因频率或基因型频率均无差异。
多态性之间的关系在确定成瘾等复杂疾病的风险特征方面可能很重要，但阿片类药物成瘾是一种多因素综合征，部分具有遗传性，部分受环境影响。
