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在生理学、癌症和其他疾病中对 HAUSP（USP7）的新认识。

Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases.

机构信息

1Signal Transduction in Cancer and Stem Cells Laboratory, Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), 4 Raja S.C. Mullick Road, Kolkata- 700032 and CN-06, Sector-V, Salt Lake, Kolkata, 700091 India.

2Department of Microbiology, Barrackpore Rastraguru Surendranath College, 6 Riverside Road and 85 Middle Road, Barrackpore, Kolkata 700120 India.

出版信息

Signal Transduct Target Ther. 2018 Jun 29;3:17. doi: 10.1038/s41392-018-0012-y. eCollection 2018.

DOI:10.1038/s41392-018-0012-y
PMID:29967688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6023882/
Abstract

Herpesvirus-associated ubiquitin-specific protease (HAUSP) is a USP family deubiquitinase. HAUSP is a protein of immense biological importance as it is involved in several cellular processes, including host-virus interactions, oncogenesis and tumor suppression, DNA damage and repair processes, DNA dynamics and epigenetic modulations, regulation of gene expression and protein function, spatio-temporal distribution, and immune functions. Since its discovery in the late 1990s as a protein interacting with a herpes virus regulatory protein, extensive studies have assessed its complex roles in p53-MDM2-related networks, identified numerous additional interacting partners, and elucidated the different roles of HAUSP in the context of cancer, development, and metabolic and neurological pathologies. Recent analyses have provided new insights into its biochemical and functional dynamics. In this review, we provide a comprehensive account of our current knowledge about emerging insights into HAUSP in physiology and diseases, which shed light on fundamental biological questions and promise to provide a potential target for therapeutic intervention.

摘要

疱疹病毒相关泛素特异性蛋白酶 (HAUSP) 是一种 USP 家族去泛素化酶。HAUSP 具有极其重要的生物学意义，因为它参与了多种细胞过程，包括宿主-病毒相互作用、致癌和肿瘤抑制、DNA 损伤和修复过程、DNA 动力学和表观遗传调节、基因表达和蛋白质功能的调节、时空分布和免疫功能。自 20 世纪 90 年代末作为一种与疱疹病毒调节蛋白相互作用的蛋白质被发现以来，广泛的研究评估了其在 p53-MDM2 相关网络中的复杂作用，确定了许多其他相互作用的伙伴，并阐明了 HAUSP 在癌症、发育以及代谢和神经病理学中的不同作用。最近的分析为其生化和功能动力学提供了新的见解。在这篇综述中，我们全面阐述了我们目前对 HAUSP 在生理和疾病中的新见解的认识，这些认识为基础生物学问题提供了启示，并有望为治疗干预提供一个潜在的靶点。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff68/6023882/4245a1337fbb/41392_2018_12_Fig1_HTML.jpg
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