King's College London, Randall Centre for Cell & Molecular Biophysics, London, UK.
Chem Commun (Camb). 2018 Jul 12;54(57):8007-8010. doi: 10.1039/c8cc04089c.
Prions are self-replicating infectious proteinaceous agents whose conformations are capable of forming amyloid-like aggregate fibrils. Here we present molecular dynamics simulations aimed at investigating the aggregation process of the β-rich H2H3 domain of the ovine prion protein (H2H3-OvPrPSc), known to be the portion of prion protein carrying oligomerization activity.
朊病毒是自我复制的传染性蛋白质颗粒，其构象能够形成类似淀粉样的聚集纤维。在这里，我们呈现了旨在研究绵羊朊病毒蛋白（H2H3-OvPrPSc）β-丰富的 H2H3 结构域的聚集过程的分子动力学模拟，该结构域已知是具有聚合活性的朊病毒蛋白的一部分。
