Fox J, Care A D
Clin Sci (Lond). 1985 Nov;69(5):549-52. doi: 10.1042/cs0690549.
We have used pigs with inherited vitamin D-dependent rickets type 1 to study the effect of 1,25-dihydroxyvitamin D deficiency on the metabolic clearance rate of 3H-1,25-dihydroxyvitamin D3 infused to steady-state levels in plasma. Plasma levels of 1,25-dihydroxyvitamin D were 24 +/- 1 (SEM) pmol/l in the hypocalcaemic, homozygous piglets and 196 +/- 27 pmol/l in their normocalcaemic, heterozygous siblings. The metabolic clearance rate of 1,25-dihydroxyvitamin D3 was the same in both normal heterozygous (0.90 +/- 0.02) and hypocalcaemic, homozygous piglets (0.90 +/- 0.01 ml-1 min-1 kg-1 metabolic body size). We conclude that a deficiency of circulating 1,25-dihydroxyvitamin D does not influence the clearance of 1,25-dihydroxyvitamin D3 from the circulation of pigs.
我们使用患有遗传性1型维生素D依赖性佝偻病的猪，来研究1,25 - 二羟维生素D缺乏对输注至血浆稳态水平的3H - 1,25 - 二羟维生素D3代谢清除率的影响。低血钙的纯合仔猪血浆1,25 - 二羟维生素D水平为24±1（标准误）pmol/L，其血钙正常的杂合同胞仔猪血浆1,25 - 二羟维生素D水平为196±27 pmol/L。正常杂合仔猪（0.90±0.02）和低血钙纯合仔猪（0.90±0.01 ml-1 min-1 kg-1代谢体重）的1,25 - 二羟维生素D3代谢清除率相同。我们得出结论，循环中1,25 - 二羟维生素D缺乏不会影响猪体内1,25 - 二羟维生素D3从循环中的清除。
