Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America.
Phys Med Biol. 2018 Aug 1;63(15):155017. doi: 10.1088/1361-6560/aad0c2.
Focused ultrasound is now capable of noninvasively penetrating the intact human skull and delivering energy to specific areas of the brain with millimeter accuracy. The ultrasound energy is supplied in high-intensities to create brain lesions or at low-intensities to produce reversible physiological interventions. Conducting acoustic emission detection (AED) and electroencephalography (EEG) during transcranial focused ultrasound may lead to several new brain treatment and research applications. This study investigates the feasibility of using a novel scalp senor for acquiring concurrent AED and EEG during clinical transcranial ultrasound. A piezoelectric disk is embedded in a plastic cup EEG electrode to form the sensor. The sensor is coupled to the head via an adhesive/conductive gel-dot. Components of the sensor prototype are tested for AED and EEG signal quality in a bench top investigation with a functional ex vivo skull phantom.
聚焦超声现在能够无创穿透完整的人类颅骨，并以毫米级的精度将能量传递到大脑的特定区域。超声能量以高强度提供，以产生脑损伤，或以低强度产生可逆的生理干预。在经颅聚焦超声过程中进行声发射检测（AED）和脑电图（EEG）可能会带来几种新的大脑治疗和研究应用。本研究探讨了在临床经颅超声中使用新型头皮传感器同时获取 AED 和 EEG 的可行性。将压电盘嵌入到塑料杯 EEG 电极中以形成传感器。通过使用粘性/导电凝胶点将传感器耦合到头骨上。在具有功能的离体颅骨模型的台式研究中，对传感器原型的组件进行了 AED 和 EEG 信号质量的测试。
