Saeed Anjum, Assiri Asaad M, Al Asmi Mona, Ullah Anhar
Division of Pediatric Gastroenterology, Hepatology & Nutrition, Department of Pediatric Medicine, College of Medicine, King Saud University Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2018 Jul;39(7):668-673. doi: 10.15537/smj.2018.7.22425.
To observe the frequency of eosinophilic esophagitis (EoE), pattern of clinical presentation and diagnosis among Saudi children at 2 tertiary carehospitals in Riyadh, Saudi Arabia.
The database of children admitted or seen, and aged less than 18 years over 5 years period and diagnosed with EoE was collected and reviewed. Patients with esophagitis other than EoE were excluded. Patients who had eosinophils count more than 15/high power field (HPF) on esophageal biopsies were given the diagnosis of EoE. Demographic database, clinical parameters, and diagnostic modalities were analyzed by using the Statistical Package for Social Sciences version 22.
A total of 37 children with the diagnosis of EoE were gathered from 398 upper gastrointestinal endoscopic procedures with the frequency of 9.3%. There were 22 (59.4%) males with a mean±SD age of 9.6±2.3 years and all were Saudi nationals. Dysphagia was the leading presentation in 21 (56.7%) children followed by vomiting in 18 (48.6%), impaction of food bolus in 8 (21.6%) and foreign body in 3 (8.1%). Allergic symptoms were present in 13 (35.1%) children in the form of asthma, 11 (29.7%) multiple food allergies and 5 (13.5%) eczema. Peripheral eosinophil count and immunoglobulin E were raised more than normal in 6 and 5 children respectively. The pH measurements were carried out in 16 (43.2%) and ruled out the reflux. Contrast studies with barium (n=6; 16.2%) and endoscopic findings were significant (n=27; 72.9%).
Eosinophilic esophagitis is an emerging disease and have a rising trend in Saudi children. Dysphagia, vomiting, and food impaction are the more common presenting features in older children and recurrent vomiting in younger children in addition to associated allergic conditions.
观察沙特阿拉伯利雅得两家三级医疗医院中沙特儿童嗜酸性粒细胞性食管炎（EoE）的发病率、临床表现模式及诊断情况。
收集并回顾5年间收治的年龄小于18岁且诊断为EoE的儿童数据库。排除患有除EoE以外食管炎的患者。食管活检中嗜酸性粒细胞计数超过15/高倍视野（HPF）的患者被诊断为EoE。使用社会科学统计软件包第22版分析人口统计学数据库、临床参数和诊断方式。
在398例上消化道内镜检查中，共确诊37例EoE患儿，发病率为9.3%。其中男性22例（59.4%），平均年龄9.6±2.3岁，均为沙特国民。吞咽困难是21例（56.7%）患儿的主要表现，其次是呕吐18例（48.6%）、食物团块嵌塞8例（21.6%）和异物3例（8.1%）。13例（35.1%）患儿有过敏症状，表现为哮喘、11例（29.7%）多种食物过敏和5例（13.5%）湿疹。分别有6例和5例患儿外周嗜酸性粒细胞计数和免疫球蛋白E高于正常水平。16例（43.2%）患儿进行了pH测量，排除了反流。6例（16.2%）进行了钡剂造影检查，内镜检查结果显著（27例，72.9%）。
嗜酸性粒细胞性食管炎是一种新兴疾病，在沙特儿童中有上升趋势。吞咽困难、呕吐和食物嵌塞是大龄儿童较常见的表现特征，而幼儿除伴有过敏情况外，反复呕吐更为常见。
