Alzanbagi Mashael A, Milyani Asmaa A, Al-Agha Abdulmoein E
Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2018 Jul;39(7):674-678. doi: 10.15537/smj.2018.7.22193.
To evaluate the growth parameters in congenital adrenal hyperplasia patients in Jeddah, Saudi Arabia. Methods: This is a descriptive retrospective study over the period of 5 years. Data analysis was using Statistical Package for Social Science. The study included 90 participants in which 61 were girls and 29 were boys aged 0 to 18 years . They were evaluated in Pediatric Endocrinology Clinic at King Abdulaziz University Hospital in Jeddah, Saudi Arabia, between January 2012 and January 2017.
A total of 90 subjects, of which 67.8% were females and 32.2% were males. Subjects who were underweight constituted 19.1% of the population, while those who were obese were estimated up to 17.6% of the population. Of the children, 25.7% were suffering from short stature and 74.3% had normal height. Approximately 11.8% of the children who suffered from short stature also suffered from hypothyroidism. Mid-parental height of those who suffered from short stature is 159.8 cm.
This study showed a significant effect of congenital adrenal hyperplasia on both height, weight, and body mass index. Risk factors includes glucocorticoids dosage, compliance to treatment, and regular follow up. Personalized treatment approach should be followed with all patients diagnosed with congenital adrenal hyperplasia as well as close monitoring and targeted therapy.
评估沙特阿拉伯吉达先天性肾上腺皮质增生症患者的生长参数。方法：这是一项为期5年的描述性回顾性研究。数据分析采用社会科学统计软件包。该研究纳入了90名参与者，其中61名女孩和29名男孩，年龄在0至18岁之间。他们于2012年1月至2017年1月在沙特阿拉伯吉达阿卜杜勒阿齐兹国王大学医院儿科内分泌诊所接受评估。
共有90名受试者，其中67.8%为女性，32.2%为男性。体重过轻的受试者占总人数的19.1%，而肥胖者估计占总人数的17.6%。在这些儿童中，25.7%患有身材矮小，74.3%身高正常。身材矮小的儿童中约11.8%也患有甲状腺功能减退症。身材矮小者的父母平均身高为159.8厘米。
本研究表明先天性肾上腺皮质增生症对身高、体重和体重指数均有显著影响。危险因素包括糖皮质激素剂量、治疗依从性和定期随访。对于所有诊断为先天性肾上腺皮质增生症的患者，应采用个性化治疗方法，并进行密切监测和靶向治疗。
