University of Campania 'Luigi Vanvitelli' - School of Medicine, Department of Precision Medicine, Division of Medical Oncology, Via Pansini n.5, 80131 Naples, Italy.
University of Campania 'Luigi Vanvitelli'- Division of GI Tract Surgical Oncology, Department of Surgical Sciences, Via Pansini n.5, 80131 Naples, Italy.
Future Oncol. 2018 Oct;14(24):2493-2505. doi: 10.2217/fon-2018-0167. Epub 2018 Jul 3.
Systemic inflammatory response affects survival of gastric cancer (GC) patients. This study was carried out to create a prognostic inflammatory-based score to predict survival in metastatic GC (mGC) before first-line chemotherapy.
MATERIALS & METHODS: We studied the prognostic value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio in 151 patients with mGC at the diagnosis.
Median overall survival (OS) was significantly lower in patients with high NLR. Performance status 1-2 according to the Eastern Cooperative Oncology Group scale and NLR were predictors of shorter OS at multivariate analysis. Based on these results, we defined a prognostic OS score, showing a better median OS in favorable risk group.
Elevated pretreatment NLR and Eastern Cooperative Oncology Group are independent predictors of shorter OS in mGC patients before first-line chemotherapy.
全身炎症反应会影响胃癌（GC）患者的生存。本研究旨在建立一种基于炎症的预后评分，以预测一线化疗前转移性 GC（mGC）患者的生存情况。
我们研究了 NLR 和血小板-淋巴细胞比值在 151 例 mGC 患者诊断时的预后价值。
高 NLR 组的中位总生存期（OS）显著降低。根据东部肿瘤协作组（ECOG）量表，体力状态 1-2 分和 NLR 是多因素分析中 OS 较短的预测因素。基于这些结果，我们定义了一个预后 OS 评分，显示在低危组中有更好的中位 OS。
在接受一线化疗前，mGC 患者的 NLR 升高和 ECOG 是 OS 较短的独立预测因素。
