Racz K, Kuchel O, Cantin M, De Léan A
FEBS Lett. 1985 Nov 11;192(1):19-22. doi: 10.1016/0014-5793(85)80034-x.
We have previously determined that atrial natriuretic factor (ANF) is a potent inhibitor of steroid secretion in cultured bovine zona glomerulosa and fasciculata cells. The present report describes a comparison of the effect produced by ANF on aldosterone, deoxycorticosterone and progesterone secretions by zona glomerulosa cells and on cortisol, corticosterone and progesterone secretions by zona fasciculata cells. The equipotent inhibitory action of ANF on the stimulated secretion of these steroids in both cell types indicates a common site of action prior to progesterone synthesis at which ANF inhibits the steroidogenic pathway.
我们之前已确定，心房利钠因子（ANF）是培养的牛肾小球带和束状带细胞中类固醇分泌的强效抑制剂。本报告描述了ANF对肾小球带细胞醛固酮、脱氧皮质酮和孕酮分泌以及对束状带细胞皮质醇、皮质酮和孕酮分泌所产生影响的比较。ANF对这两种细胞类型中这些类固醇刺激分泌的等效抑制作用表明，在孕酮合成之前存在一个共同的作用位点，ANF在该位点抑制类固醇生成途径。
