Molecular Toxicology Group, Dept. of Biology, University of Konstanz, D-78457 Konstanz, Germany.
Molecular Toxicology Group, Dept. of Biology, University of Konstanz, D-78457 Konstanz, Germany.
Mech Ageing Dev. 2019 Jan;177:128-134. doi: 10.1016/j.mad.2018.06.006. Epub 2018 Jun 30.
Ageing is a multifactorial process that affects most, if not all, of the body's tissues and organs and can be defined as the accumulation of physical and psychological changes in a human being over time. The rate of ageing differs between individuals of the same chronological age, meaning that 'biological age' of a person may be different from 'chronological age'. Furthermore, ageing represents a very potent risk factor for diseases and disability in humans. Therefore, establishment of markers of biological ageing is important for preventing age-associated diseases and extending health span. MARK-AGE, a large-scale European study, aimed at identifying a set of biomarkers which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. But beyond the identification of useful biomarkers, MARK-AGE provided new insights in age-associated specific cellular processes, such as DNA methylation, oxidative stress and the regulation of zinc homeostasis.
衰老是一个多因素的过程，影响着人体的大多数（如果不是全部）组织和器官，可以定义为一个人随着时间的推移而在身体和心理上发生的变化的积累。同一实际年龄的个体之间衰老的速度不同，这意味着一个人的“生物年龄”可能与“实际年龄”不同。此外，衰老是人类患病和残疾的一个非常重要的危险因素。因此，建立生物衰老的标志物对于预防与年龄相关的疾病和延长健康寿命非常重要。MARK-AGE 是一项大型的欧洲研究，旨在确定一组生物标志物，这些标志物作为具有适当权重的参数组合，将比任何单独的标志物更能准确地衡量生物年龄。但除了识别有用的生物标志物外，MARK-AGE 还提供了与年龄相关的特定细胞过程的新见解，如 DNA 甲基化、氧化应激和锌稳态的调节。
