Chen Jeon-Hor, Zhang Yang, Chan Siwa, Chang Ruey-Feng, Su Min-Ying
Center For Functional Onco-Imaging of Department of Radiological Sciences, University of California, Irvine, CA, USA; Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan.
Center For Functional Onco-Imaging of Department of Radiological Sciences, University of California, Irvine, CA, USA.
Magn Reson Imaging. 2018 Nov;53:34-39. doi: 10.1016/j.mri.2018.06.019. Epub 2018 Jun 30.
The aim of this study was to develop morphological analytic methods to analyze the tumor-fat interface and in different peritumoral shells away from the tumor, and to compare the results among three molecular subtypes of breast cancer.
A total of 102 women (mean age 48.5 y/o) with solitary well-defined breast cancers were analyzed, including 46 human epidermal growth factor receptor 2 (HER2) (+), 46 HER2(-) hormonal receptor (HR) (+), and 10 triple negative (TN) breast cancers. The tumor lesion, the breast, the fibroglandular and fatty tissue were segmented using well-established methods. The whole breast fat percentage and the peri-tumor interface fat percentage were measured. Three shells (SH1, SH2, SH3) surrounding the convex hall of the three dimensional (3D) tumor were defined and in each shell the volumetric percentage of fat was calculated. The peri-tumor interface fat percentage and the volumetric percentage of fat in the three peri-tumoral shells were compared among different subtypes.
In the TN group, the fat percentage on the tumor boundary was 43 ± 20% and 78 ± 12% for two dimensional (2D) and 3D measurement, respectively, which were the highest among the three subtypes but not significantly different. The fat percentage in SH2 and SH3 in the TN group was 82 ± 7% and 85 ± 7%, which was significantly higher compared to the two other two subtypes. The results remained after controlling for the whole breast fat percentage.
This study provided a feasible method for quantitative analysis of peri-tumoral tissue characteristics. Because of small patient number, the finding that TN tumors had the highest peri-tumor fat content among the three subtypes needs to be further verified with a large cohort study.
本研究旨在开发形态学分析方法，以分析肿瘤-脂肪界面以及远离肿瘤的不同瘤周层，并比较三种分子亚型乳腺癌的分析结果。
共分析了102例患有孤立性边界清晰乳腺癌的女性（平均年龄48.5岁），其中包括46例人表皮生长因子受体2（HER2）阳性、46例HER2阴性激素受体（HR）阳性以及10例三阴性（TN）乳腺癌患者。采用成熟方法对肿瘤病灶、乳房、纤维腺组织和脂肪组织进行分割。测量全乳脂肪百分比和瘤周界面脂肪百分比。定义围绕三维（3D）肿瘤凸面的三个层（SH1、SH2、SH3），并计算每个层中的脂肪体积百分比。比较不同亚型之间的瘤周界面脂肪百分比和三个瘤周层中的脂肪体积百分比。
在TN组中，肿瘤边界处的脂肪百分比在二维（2D）测量时为43±20%，在三维（3D）测量时为78±12%，是三种亚型中最高的，但差异无统计学意义。TN组中SH2和SH3层的脂肪百分比分别为82±7%和85±7%，与其他两种亚型相比显著更高。在控制全乳脂肪百分比后，结果依然如此。
本研究提供了一种定量分析瘤周组织特征的可行方法。由于患者数量较少，TN肿瘤在三种亚型中瘤周脂肪含量最高这一发现需要通过大规模队列研究进一步验证。
