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一种预测钻孔引流术后慢性硬膜下血肿复发的可靠列线图模型。

A Reliable Nomogram Model to Predict the Recurrence of Chronic Subdural Hematoma After Burr Hole Surgery.

作者信息

Yan Chao, Yang Ming-Fei, Huang Yong-Wei

机构信息

Graduate School, Qinghai University, Xining, Qinghai, China.

Department of Neurosurgery, Qinghai Provincial People's Hospital, Xining, Qinghai, China.

出版信息

World Neurosurg. 2018 Oct;118:e356-e366. doi: 10.1016/j.wneu.2018.06.191. Epub 2018 Jun 30.

Abstract

OBJECTIVE

We established a reliable nomogram model to predict the recurrence of chronic subdural hematoma (CSDH) after burr hole surgery.

METHODS

We retrospectively analyzed 514 patients who were treated in our hospital between January 2010 and November 2017 and included 231 patients in this study. We used univariate and binary logistic regression analysis to identify the significantly related predictors for recurrence. Subsequently, we established the nomogram model using these predictors and validated it.

RESULTS

The total rate of recurrence after initial surgery for CSDH was 14.29% (33/231) during the following 3 months. We found that preoperative hematoma volume (greater than 121 mL), postoperative residual cavity volume (greater than 72 mL), computed tomography scan imaging type (hyper- and mixed-density type), and age (older than 65 years of age) were significantly related to recurrence. We used 50% recurrence rate as the classification cutoff, with the corresponding points of 252 to validate the nomogram model. The accuracy of predicting the recurrence of CSDH calculated by the binary logistic regression model was 91.7%. The sensitivity and specificity of the nomogram were 87.88% and 84.85%, respectively.

CONCLUSIONS

This nomogram model had a high precision to predict the recurrence of CSDH. It needs more external and prospective validation in the future. We expect this model could be used in different neurosurgical problems as well.

摘要

目的

我们建立了一个可靠的列线图模型,以预测钻孔手术后慢性硬膜下血肿(CSDH)的复发情况。

方法

我们回顾性分析了2010年1月至2017年11月在我院接受治疗的514例患者,本研究纳入了231例患者。我们采用单因素和二元逻辑回归分析来确定与复发显著相关的预测因素。随后,我们使用这些预测因素建立了列线图模型并进行了验证。

结果

CSDH初次手术后3个月内的总复发率为14.29%(33/231)。我们发现术前血肿体积(大于121 mL)、术后残余腔体积(大于72 mL)、计算机断层扫描成像类型(高密度和混合密度类型)以及年龄(大于65岁)与复发显著相关。我们以50%的复发率作为分类临界值,对应点数为252来验证列线图模型。二元逻辑回归模型计算出的预测CSDH复发的准确率为91.7%。列线图的敏感性和特异性分别为87.88%和84.85%。

结论

该列线图模型在预测CSDH复发方面具有较高的精度。未来需要更多的外部和前瞻性验证。我们期望该模型也可用于不同的神经外科问题。

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