Sato H, Matsuda M, Ikuta M, Hada Y, Kusumoto G, Kirimoto K
Gynecol Oncol. 1985 Oct;22(2):240-3. doi: 10.1016/0090-8258(85)90032-0.
A 65-year-old previously healthy housewife, gravida 3, para 3, was first diagnosed as Stage Ib carcinoma of the uterine cervix (poorly differentiated squamous cell carcinoma) and admitted. The external radiation of 5400 rad by telecobalt source was performed. No intracavitary radiation was added. After about 7 1/2 years the patient noticed a tumor of fist size on her buttocks, but she did not present in our clinic regularly. Because of enlarging tumor and general malaise she was readmitted a year later. On the fifth hospital day she died with ileus. Autopsy revealed osteosarcoma of buttocks in the radiation field, stomach cancer (tubular adenocarcinoma) with perforated peritonitis, and invasive mole of the uterine corpus. The patient's last pregnancy terminated as a full-term delivery at 26 years of age and she was 43 years at her menopause. The dormant period of invasive mole was 47 years after her last pregnancy, 30 years after her menopause, and at least 8 years after pelvic radiation.
一位65岁、既往健康的家庭主妇，孕3产3，首次被诊断为子宫颈Ib期癌（低分化鳞状细胞癌）并入院。采用钴远距离治疗机进行了5400拉德的体外照射，未加腔内照射。约7年半后，患者发现臀部有拳头大小的肿物，但未定期到我院就诊。由于肿物增大及全身不适，1年后再次入院。住院第5天，患者因肠梗阻死亡。尸检发现放疗野内臀部骨肉瘤、伴有穿孔性腹膜炎的胃癌（管状腺癌）以及子宫体侵袭性葡萄胎。患者最后一次妊娠于26岁时足月分娩，43岁绝经。侵袭性葡萄胎的潜伏期为最后一次妊娠后47年、绝经后30年以及盆腔放疗后至少8年。
