VEGF、CD31和αSMA在原发性肺癌切除标本中的表达及其预后影响
Expression and Prognostic Impact of VEGF, CD31 and αSMA in Resected Primary Lung Cancers.
作者信息
Usuda Katsuo, Iwai Syun, Funasaki Aika, Sekimura Atsushi, Motono Nozomu, Ueda Yoshimiti, Shimazaki Miyako, Uramoto Hidetaka
机构信息
Department of Thoracic Surgery, Kanazawa Medical University, Ishikawa, Japan
Department of Thoracic Surgery, Kanazawa Medical University, Ishikawa, Japan.
出版信息
Anticancer Res. 2018 Jul;38(7):4057-4063. doi: 10.21873/anticanres.12695.
BACKGROUND/AIM: One of the most important factors concerning cancer growth is angiogenesis. The purpose of this study was to clarify the relationship of maturation of tumor vessels and prognosis of lung cancer.
MATERIALS AND METHODS
Immunohistochemical stainings of 125 lung cancers for VEGF, CD31 and α-smooth muscle actin (αSMA) were scored by multiplying the intensity and the frequency from 0 to 12.
RESULTS
Adenocarcinomas showed significantly higher staining scores of both VEGF and αSMA than squamous cell carcinomas did. In 42 cases of high CD31 score, five-year survival rate (87%) of patients with lung cancer showing mature tumor vessels was significantly better than that (69%) of patients with immature tumor vessels.
CONCLUSION
Not the number of tumor vessels but their maturation may be a prognostic factor of patients with lung cancer. VEGF may not only stimulate proliferation of endothelial cells but also their maturation in differentiated lung cancers.
背景/目的：与癌症生长相关的最重要因素之一是血管生成。本研究的目的是阐明肿瘤血管成熟与肺癌预后之间的关系。
材料与方法
对125例肺癌进行血管内皮生长因子（VEGF）、CD31和α平滑肌肌动蛋白（αSMA）的免疫组织化学染色，通过强度和频率相乘计分，范围为0至12分。
结果
腺癌的VEGF和αSMA染色评分均显著高于鳞状细胞癌。在CD31评分高的42例患者中，肿瘤血管成熟的肺癌患者五年生存率（87%）显著高于肿瘤血管不成熟的患者（69%）。
结论
对于肺癌患者，可能不是肿瘤血管数量而是其成熟度是一个预后因素。在分化型肺癌中，VEGF不仅可能刺激内皮细胞增殖，还可能促进其成熟。
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