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Synthesis of Z-CCK-27-32-NH2, Z-Tyr(SO-3)-Met-Gly-Trp-Met-Asp-NH2, a cholecystokinin receptor antagonist and an inhibitor of gastrin-induced acid secretion.

作者信息

Briet C, Aumelas A, Martinez J

出版信息

Int J Pept Protein Res. 1985 Sep;26(3):294-8. doi: 10.1111/j.1399-3011.1985.tb03207.x.

DOI:10.1111/j.1399-3011.1985.tb03207.x
PMID:2997059
Abstract

The synthesis of the hexapeptide Z-Tyr(SO-3)-Met-Gly-Trp-Met-Asp-NH2, representing the C-terminal sequence of cholecystokinin minus the C-terminal phenylalanyl residue is described. This peptide was shown to be the most potent cholecystokinin receptor antagonist in vitro described to date. It is also able to inhibit gastrin-induced acid secretion in vivo, in the rat and was proved to antagonize the action of the C-terminal octapeptide of cholecystokinin in the central nervous system.

摘要

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