George Tinu, Kumaran Parvathy, Varma R Balagopal, Xavier Arun Mamachan, Janardhanan Suresh Kumar, Govinda Bhat Sangeetha
Department of Pedodontics, Amrita School of Dentistry, Kochi, Kerala, India.
J Indian Soc Pedod Prev Dent. 2018 Apr-Jun;36(2):130-134. doi: 10.4103/JISPPD.JISPPD_211_17.
The efficacy of dental treatment on the levels of inflammatory markers in ventricular septal defect (VSD) has not been fully explored.
The aim of this study was to assess the level of salivary interleukin-6 (IL-6) in children with early childhood caries (ECC) and VSD and to compare its levels before and after comprehensive full mouth rehabilitation.
Saliva samples were collected from children with ECC and VSD before dental treatment and 1-month posttreatment. The salivary IL-6 levels were analyzed using the enzyme-linked immunosorbent assay method. Gingival index (GI) was also timely recorded during the study period. Oral health awareness sessions were conducted for children and their parents. The Fisher's Least Significant Difference test was used for intergroup comparison of salivary IL-6 levels, while the paired t-test compared the values of GI before and after treatment.
The mean salivary IL-6 levels 1 month after treatment had reduced (P < 0.000). There was a reduction in GI score (P = 0.002).
When children having VSD and ECC are dentally rehabilitated and followed up periodically, the level of IL-6 is minimized, hence improving the quality of life of the affected children.
牙科治疗对室间隔缺损（VSD）患者炎症标志物水平的疗效尚未得到充分研究。
本研究旨在评估患有幼儿龋（ECC）和VSD的儿童唾液白细胞介素-6（IL-6）水平，并比较全口综合康复治疗前后的水平。
在牙科治疗前和治疗后1个月收集患有ECC和VSD的儿童的唾液样本。采用酶联免疫吸附测定法分析唾液IL-6水平。在研究期间还及时记录牙龈指数（GI）。为儿童及其家长开展口腔健康宣传活动。采用Fisher最小显著差异检验对唾液IL-6水平进行组间比较，而配对t检验比较治疗前后GI值。
治疗1个月后唾液IL-6平均水平降低（P < 0.000）。GI评分降低（P = 0.002）。
对患有VSD和ECC的儿童进行牙科康复治疗并定期随访时，IL-6水平可降至最低，从而改善患病儿童的生活质量。
