Ma Yan, Chen Yanfang, Chen Lei, Liu Zhi, Ieong Mio-Leng, Gao Fei, Huang Wei
Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
J Cancer Res Ther. 2018;14(4):844-850. doi: 10.4103/jcrt.JCRT_605_17.
This study aims to investigate the involvement of insulin-like growth factor II (IGF-II) in human hepatocellular carcinoma (HCC) proliferation and metastasis.
The effects of IGF-II on cell proliferation, cell cycle, apoptosis, cell migration, and invasion in HCC Huh7 cells were investigated in the study.
IGF-II promoted cell proliferation and colony formation, suppressed cell apoptosis in Huh7 cells by promoting cell cycle progression, induced epithelial-mesenchymal transition (EMT) phenotypes, and enhanced the metastatic potential of HCC in vitro.
Our results revealed that IGF-II promotes cell proliferation and EMT in HCC cells.
本研究旨在探讨胰岛素样生长因子II（IGF-II）在人肝细胞癌（HCC）增殖和转移中的作用。
本研究调查了IGF-II对肝癌Huh7细胞的细胞增殖、细胞周期、细胞凋亡、细胞迁移和侵袭的影响。
IGF-II促进细胞增殖和集落形成，通过促进细胞周期进程抑制Huh7细胞的细胞凋亡，诱导上皮-间质转化（EMT）表型，并在体外增强肝癌的转移潜能。
我们的结果表明，IGF-II促进肝癌细胞的增殖和EMT。
